Severe hypertriglyceridemia can present with eruptive xanthomas, which are reversible with appropriate lipid-lowering pharmacotherapy.
Eruptive xanthoma signals extreme hypertriglyceridemia requiring urgent care; single case leaves open screening impact on ASCVD outcomes.
Xanthomas are benign cutaneous manifestations of extracellular lipid accumulation. Eruptive xanthoma is characterized by the acute, widespread presentation of a papular rash and usually involves the back, buttocks, and extremities. Eruptive xanthoma is associated with hyperlipidemia, hypertriglyceridemia, and an increased long-term risk of atherosclerotic cardiovascular disease. We present a case of eruptive xanthoma accompanied by severe hypertriglyceridemia (10,164 mg/dL) in which the course of the disease was reversed following implementation of lipid-lowering pharmacotherapy.
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Spiro et al. (2021) studied this question.
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