Intensive Immunization of Man

Article1 July 1965Intensive Immunization of ManEvaluation of Possible Adverse ConsequencesRICHARD N. PEELER, M.D., PAUL J. KADULL, M.D., LEIGHTON E. CLUFF, M.D., F.A.C.P.RICHARD N. PEELER, M.D., PAUL J. KADULL, M.D., LEIGHTON E. CLUFF, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-1-44 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince 1902, when Zenoni (1) first described the occurrence of amyloidosis in horses intensively immunized to diphtheria toxin, there have been numerous reports of animal experiments in which amyloidosis, as well as arteritis and other manifestations of hypersensitivity, have been induced by the injection of many different antigenic agents (2-21). That such adverse reactions to immunization have not been observed in man is doubtlessly related to the relatively trivial doses of antigen to which the human being is usually exposed. 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Peeler, M.D., Department of Medicine, The Johns Hopkins Hospital, Baltimore, Md. 21205. 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FRED AYVAZIAN, M.D.Repeated Immunization: Possible Adverse Effects Reevaluation of Human Subjects at 25 YearsCHARLES S. WHITE III, M.D., WILLIAM H. ADLER, M.D., VIRGINIA G. McGANN, Ph.D.Selected Topics in ImmunizationExperimental amyloidosis in hamstersImmunization and ArthritisSudden unexplained death in infancy and hyperimmunizationActive Immunisation against TetanusIatrogenic Factors in Infectious DiseaseHARRY N. BEATY, M.D., ROBERT G. PETERSDORF, M.D., F.A.C.P.Wheezing Associated With Respiratory Tract Infections In ChildrenDiffuse Vasculitis and Death after Hyperimmunization with Pertussis Vaccine 1 July 1965Volume 63, Issue 1Page: 44-57KeywordsAdverse reactionsAmyloidosisAntigensBacterial pathogensDiphtheriaHospital medicineInfectious diseasesProteinsRocky Mountain spotted feverToxins Issue Published: 1 July 1965 PDF downloadLoading ...