Why the study?
Does moderate-intensity aerobic exercise improve cardiac function and reduce myocardial fibrosis in a rat model of myocardial infarction?
Population
48 male Sprague-Dawley rats with myocardial infarction induced by left anterior descending coronary artery…
Comparison
Moderate-intensity aerobic exercise. vs Sedentary rats with myocardial infarction and…
Design
Preclinical, Randomly assigned to three groups
Follow-up
8 weeks
Authors
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Hypothesis-generating for M3-mediated exercise benefits in MI; leaves open human translation before any practice change.
Does moderate-intensity aerobic exercise improve cardiac function and reduce myocardial fibrosis in a rat model of myocardial infarction?
Moderate-intensity aerobic exercise ameliorates cardiac dysfunction and reduces myocardial fibrosis and apoptosis in rats post-myocardial infarction, likely by up-regulating the M3 receptor pathway.
Huang Shou-jun (2016) studied this question.
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