Perturbation of cellular thiol homeostasis occurs during the early phase of oxidative cell injury in isolated hepatocytes. This perturbation, involves depletion of soluble and protein-bound thiols, and is associated with altered intracellular calcium (Ca") homeostasis resulting from inhibition of major Ca2+ transport systems. The result is sustained increase in cytosolic Ca2+ concentration which appears to trigger cytotoxicity.
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Bellomo et al. (1985) studied this question.
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