November 1, 1990Journal of NeuroscienceOpen Access

Inhibition of agrin-induced acetylcholine-receptor aggregation by heparin, heparan sulfate, and other polyanions

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Population

Preclinical model (developing neuromuscular junctions / myotubes)

Design

Preclinical

Authors

BWBruce G. WallaceUniversity of Colorado Health

Discussion

Member takes

Implication

Hypothesis-generating for proteoglycan regulation of agrin; leaves open in vivo relevance and any clinical translation.

Structured PICO

Population

Preclinical model (developing neuromuscular junctions / myotubes)

Intervention

Heparin, heparan sulfate, and other polyanions

Outcome

Inhibition of agrin-induced acetylcholine-receptor (AChR) aggregationsurrogate

Polyanions like heparin inhibit agrin-induced AChR aggregation by forming an inactive complex with agrin, suggesting a role for sulfated proteoglycans in agrin-receptor interactions.

Cite This Study

Bruce G. Wallace (1990) studied this question.

synapsesocial.com/papers/6a9287936cd82e5620979eac https://doi.org/10.1523/jneurosci.10-11-03576.1990

View Full Paper

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Inhibition of agrin-induced acetylcholine-receptor aggregation by heparin, heparan sulfate, and other polyanions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of agrin-induced acetylcholine-receptor aggregation by heparin, heparan sulfate, and other polyanions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider