Answers are grounded in this paper and cite their sources.
In a patient with chronic renal failure and maintained with regular hemodialysis, the development of neuropsychiatric untoward effects during amantadine therapy was associated with an inordinately elevated plasma level of the drug. It is recommended that in the face of renal inadequacy, adjustment of the dosage of the drug should be done in accordance with the degree of renal dysfunction.
No takes yet. Share an insight, caveat, or question.
Armbruster et al. (2008) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: