Dysregulation of Nrf2 Signaling in Diabetes: An Opportunity for a Multitarget Approach

Oxidative stress is a central feature of diabetes and plays a causal role in the pathogenesis of diabetic complications. The nuclear factor-like 2 (Nrf2) transcription factor mediates the induction of antioxidant and cytoprotective genes and is a major regulator of the endogenous antioxidant and detoxification systems. Multiple aspects of the Nrf2 signaling pathway are aberrant in diabetes and simultaneously targeting the dysregulated aspects of the Nrf2 signaling pathway ought to be considered.