Why the study?
Is blood platelet uptake of serotonin altered in men alcoholics compared to nonalcoholic controls?
Is blood platelet uptake of serotonin altered in men alcoholics compared to nonalcoholic controls?
Blood platelet serotonin uptake is significantly reduced in recently detoxified male alcoholics, suggesting serotonergic dysfunction.
Blood platelet uptake of 3H-serotonin (5HT uptake) was determined in a group of inpatient alcoholics who had just undergone detoxication (N = 19) and an age-matched group of nonalcoholic controls (N = 19). Mean 5HT uptake was 18% lower in the alcoholics (p less than .01). A 3-min 5HT uptake of less than 6 pmoles/10(7) platelets identified 58% of the alcoholics, but only 15% of the controls had a 5HT uptake lower than this value. These results support the hypothesis that serotonergic dysfunction may exist in alcoholics.
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Kent et al. (1985) studied this question.
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