Key result
Platelets stored for 4 days at 22°C exhibited significant serotonin uptake with a Vmax of 2.4 x 10^-18 mole/platelet/min, retaining the ability to sequester extracellular serotonin into dense granules.
Population
Fresh cytapheresis platelets and platelet concentrates stored for up to 4 days at 22°C, obtained from…
Comparison
Incubation with serotonin at 22°C. vs Fresh platelets or baseline serotonin levels…
Design
Preclinical
Follow-up
up to 4 days (storage duration)
Authors
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Animal data on preserved serotonin uptake should not change platelet storage practices; leaves open relevance to human transfusions pending clinical studies.
Absolute Event Rate: 2.4% vs 4.99%
p-value: p=<0.05
Platelets stored at 22°C for up to 4 days retain the ability to actively take up and sequester extracellular serotonin into dense granules.
Tetsuo Shimizu (1986) studied Healthy volunteers (platelet donors). In vitro storage at 22°C vs. Fresh platelets at 37°C was evaluated on Maximum serotonin uptake velocity (Vmax) (p=<0.05). Platelets stored for 4 days at 22°C exhibited significant serotonin uptake with a Vmax of 2.4 x 10^-18 mole/platelet/min, retaining the ability to sequester extracellular serotonin into dense granules.
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