Key result
DMSO reversibly inhibits platelet serotonin uptake velocity, with optimal recovery achieved through rapid addition and removal.
Why the study?
The effects of dimethylsulfoxide and cooling conditions on serotonin uptake velocity and hypotonic stress response of human platelets were not fully characterized.
Population
Human platelet concentrates
Comparison
Presence versus absence of DMSO and varying cooling rates from 2 to 10 degrees C/min
Design
Preclinical experimental study
Authors
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May guide in vitro platelet cryopreservation; leaves open clinical effects on function or transfusion outcomes.
For cryopreservation of human platelets, adding DMSO quickly before cooling and removing it quickly after thawing optimizes the recovery of serotonin uptake velocity.
Odink et al. (1976) studied Platelet preservation. Dimethylsulfoxide (DMSO) and cooling conditions was evaluated on Serotonin uptake velocity and response to hypotonic stress. Dimethylsulfoxide reversibly inhibited serotonin uptake velocity of human platelets, with best recovery observed when DMSO was added quickly before cooling and removed quickly after thawing.
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