Key result
Cryopreservation of human platelets resulted in changes in in vivo survival that corresponded to changes in serotonin uptake velocity and response to hypotonic stress.
Why the study?
Does cryopreservation affect the survival in vivo, serotonin uptake velocity, and response to hypotonic stress of human platelets compared to fresh platelets?
Population
Human platelets (51Cr-labeled autologous)
Comparison
Cryopreservation vs Fresh platelets (before cryopreservation)
Design
Preclinical
Authors
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May alter platelet viability in transfusion; leaves open human safety and efficacy validation.
Does cryopreservation affect the survival in vivo, serotonin uptake velocity, and response to hypotonic stress of human platelets compared to fresh platelets?
Cryopreservation of human platelets alters their survival, serotonin uptake, and response to hypotonic stress, but does not appear to induce hypercoagulability upon infusion.
Odink et al. (1977) studied this question. Cryopreservation vs. Fresh platelets was evaluated on Survival in vivo, serotonin uptake velocity, and response to hypotonic stress. Cryopreservation of human platelets resulted in changes in in vivo survival that corresponded to changes in serotonin uptake velocity and response to hypotonic stress.
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