Chaperones for wild molecules: A molecule's conformational flexibility can be eliminated by enclosing it with a macrocyclic mold as a [2]rotaxane (see picture) that forces it into a specific shape. After rapid cooling, the mold is removed with a laser pulse. Through this process, the molded molecule becomes a suitable candidate for high-resolution electronic excitation spectroscopy.
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Rijs et al. (2008) studied this question.
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