The human ClC‐4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N‐terminus

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Population

HEK293 cells, skeletal muscle fibers, and mouse brain homogenate

Comparison

Heterologous expression of hClC-4, hClC-4… vs hClC-3 or unrelated plasma membrane protein Ly49E

Design

Preclinical

Authors

Discussion

Defines hClC-4 ER targeting motif; leaves open its role in cardiac SR function and disease models.

Population

HEK293 cells, skeletal muscle fibers, and mouse brain homogenate

Intervention

Heterologous expression of hClC-4, hClC-4 truncations, and chimeras between hClC-4 and hClC-3 or Ly49E

Comparator

hClC-3 or unrelated plasma membrane protein Ly49E

Outcome

Subcellular localizationsurrogate

The human ClC-4 protein localizes to the endoplasmic reticulum, driven by a specific N-terminal motif (residues 14-63).

Okkenhaug et al. (2006) studied this question.

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