Population
Mammalian heart, vascular and gastrointestinal smooth muscles, and ventricular myocytes
Design
Review
Authors
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May link estradiol to myocyte survival via mitochondrial BKbeta1; hypothesis-generating for ischemic protection and requires validation.
BKbeta1 interacts with cytochrome c oxidase I in cardiac mitochondria and may be a target for modulation by female gonadal hormones to protect against ischemic injury.
Susumu Ohya (2006) studied this question.
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