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UNLABELLED: Patients with colon cancer can experience substantially different outcomes despite comparable anatomical stage, highlighting the need for molecular markers that complement conventional clinicopathological risk assessment. The interleukin-17 (IL-17) cytokine family has context-dependent roles in mucosal inflammation and tumour biology, but the prognostic relevance and cellular context of individual IL-17 receptors in colon cancer remain incompletely characterised. A prespecified family-wide analysis of 11 IL-17 ligands and receptors was performed in the GSE39582 Discovery cohort using continuous-expression Cox regression with Benjamini-Hochberg correction. The lead candidate, SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at https://doi.org/10.1007/s40203-026-00746-w.
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Jefferson et al. (2004) studied this question.
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