Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 29, 2026BMC ZoologyOpen Access

Splenic plasticity at the arid limit: dehydration is associated with microanatomical remodelling and B-cell depletion in the dromedary camel (Camelus dromedarius)

View Full Paper
Ask AI
Bookmark
Share

Authors

MFMohamed Amine FaresHigher National Veterinary SchoolAMAicha MouaneCentre Hospitalo-Universitaire Bab El OuedNENajah ElmounediUniversity of Sfax

Discussion

Loading...

Member takes

Overview

Cross-sectional study reveals splenic marginal zone atrophy and B-cell depletion in dehydrated dromedary camels, suggesting an immunological trade-off during extreme osmotic stress.

Key Points

  • To evaluate splenic marginal zone microanatomical plasticity and B-cell density across naturally occurring dehydration gradients in dromedary camels.
  • Conducted a cross-sectional morphophysiological study in 100 dromedary camels (Camelus dromedarius) in the Algerian Sahara across hyper-arid and transitional zones.
  • Quantified systemic hydration status via serum osmolality and hematocrit, and measured splenic marginal zone (MZ) thickness and B-cell density using quantitative histomorphometry and immunohistochemistry.
  • Evaluated relationships using multivariable linear regression adjusting for age, sex, and body condition, followed by statistical mediation modeling.
  • Dehydrated camels showed significant marginal zone (MZ) contraction compared to hydrated controls (157.9 ± 10.8 μm vs. 183.1 ± 9.6 μm; p < 0.001) alongside a 24% decline in B-cell density.
  • MZ thickness correlated inversely with serum osmolality (r = -0.72), with mediation analysis indicating the MZ-thickness pathway accounted for 59% of the dehydration–B-cell density association (ACME: -196.2 cells/mm²).
  • Camels residing in hyper-arid Saharan conditions experienced greater MZ contraction than those from the transitional Sahelian region.

Cite This Study

Fares et al. (2026) studied this question.

synapsesocial.com/papers/6a9299088e5d7d1fc0c10bcchttps://doi.org/10.1186/s40850-026-00284-0
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Seasonal Modulation of Splenic Immune Architecture and Proliferative Activity in the Dromedary Camel ( <i>Camelus dromedarius</i> ): An Ecological Perspective2026 · 1 citations
  2. 2Towards phenotyping adaptive traits in camels: A study of the influence of hypotonic saline solutions on blood cell area2024 · 2 citations
  3. 3Effects of long-term dehydration and quick rehydration on the camel kidney: pathological changes and modulation of the expression of solute carrier proteins and aquaporins2024 · 2 citations
  4. 4Development and Maturation of the Dromedary Spleen: Anatomical and Histological Analysis During the First Three Years of Life2024
  5. 5Histomorphometric changes during prenatal development of the spleen in different gestational phases of the dromedary camel (Camelus dromedarius)2026