The use of MYD88 and IGH polymerase chain reaction in the diagnosis and follow-up of Bing-Neel syndrome

Ke Xu; June Hyun; Robert Baker; Evan Vitsaras; Nicole Japzon; Shiwen Koay; Jahanzaib Khwaja; Jindriska Lindsay; Charalampia Kyriakou; Michael P. Lunn; Rajeev Gupta; Shirley D'Sa

doi:10.3324/haematol.2026.301145

August 27, 2026HaematologicaOpen Access

The use of MYD88 and IGH polymerase chain reaction in the diagnosis and follow-up of Bing-Neel syndrome

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Key Points

To evaluate the utility of MYD88 mutation and immunoglobulin heavy chain (IGH) gene rearrangement detection via polymerase chain reaction for diagnosing and monitoring Bing-Neel syndrome.
Analyzed the diagnostic application of polymerase chain reaction assays targeting MYD88 mutations and IGH gene clonality.
Assessed molecular assay performance for longitudinal disease tracking and surveillance during clinical follow-up.
Molecular testing using MYD88 and IGH PCR facilitates the confirmation of central nervous system involvement in Bing-Neel syndrome.
Targeted gene amplification enables sensitive tracking of clonal lymphoplasmacytic cells across therapeutic monitoring intervals.

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Implication

Diagnostic report demonstrates molecular PCR detection of MYD88 and IGH rearrangements in Bing-Neel syndrome, highlighting improved disease monitoring.

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a92991a8e5d7d1fc0c10d67 https://doi.org/10.3324/haematol.2026.301145

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The use of MYD88 and IGH polymerase chain reaction in the diagnosis and follow-up of Bing-Neel syndrome

Key Points

No abstract yet

Implication

Discussion

Cite This Study

The use of MYD88 and IGH polymerase chain reaction in the diagnosis and follow-up of Bing-Neel syndrome

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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