Experimental study demonstrates one-pot synthesis of phosphonate derivatives via Diels-Alder reaction, highlighting efficient solvent-free multicomponent pathways.
An effective one-pot synthesis of phosphonate derivatives using dielz-alder reaction of activated acetylenes with phosphoryl-2-oxo-2H-pyran is described. In these reactions, phosphoryl-2-oxo-2H-pyran is synthesized via the reaction of dialkyl acetylene dicarboxylates and alkyl bromides in the presence of trialkyl phosphites under solvent-free conditions at 50oC that provided good yields of products.
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IAU (2026) studied this question.
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