What does this research mean for the field?

Medicinal plants contain phytochemicals with significant antifungal potential through multiple mechanisms of action, though their translation into clinical therapeutics requires rigorous standardization, pharmacokinetic studies, and clinical trials. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This review examines the chemical profiles, antifungal mechanisms of action, therapeutic formulations, and clinical translation barriers of selected medicinal plants.

August 29, 2026Open Access

Exploring the Antifungal Potential of Medicinal Plants: A Review

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Authors

ADAnuradha Rawat Shruti Dhiman

Discussion

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Implication

Literature review demonstrates broad antifungal activity of botanical extracts against pathogenic fungi, highlighting opportunities for novel plant-based therapeutics.

Key Points

This review examines the chemical profiles, antifungal mechanisms of action, therapeutic formulations, and clinical translation barriers of selected medicinal plants.
Gathered and synthesized secondary evidence from research articles, systematic reviews, review articles, book chapters, and electronic databases.
Evaluated bioactive phytochemical classes alongside specific plant species, primarily Azadirachta indica, Ocimum sanctum, Aloe vera, Hibiscus rosa-sinensis, and Bougainvillea spectabilis.
Identified that major phytochemical classes—including alkaloids, flavonoids, tannins, terpenoids, and phenols—exert antifungal effects via membrane permeability disruption, inhibition of ergosterol biosynthesis, oxidative stress, and metabolic interference.
Found robust evidence of antifungal efficacy against Candida species for neem, tulsi, and aloe, whereas Hibiscus rosa-sinensis and Bougainvillea spectabilis demonstrated mostly in vitro activity.
Determined that wide pharmaceutical translation remains hindered by variable bioactive concentrations, plant origin disparities, formulation issues, uncharacterized pharmacokinetics, and a lack of randomized clinical trials.

Cite This Study

Anuradha Rawat Shruti Dhiman (2026) studied this question.

synapsesocial.com/papers/6a9299338e5d7d1fc0c10f74 https://doi.org/10.5281/zenodo.22124631

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August 29, 2026Open Access

Exploring the Antifungal Potential of Medicinal Plants: A Review

View Full Paper

Ask AI

Bookmark

Authors

ADAnuradha Rawat Shruti Dhiman

Discussion

Member takes

Implication

Literature review demonstrates broad antifungal activity of botanical extracts against pathogenic fungi, highlighting opportunities for novel plant-based therapeutics.

Key Points

This review examines the chemical profiles, antifungal mechanisms of action, therapeutic formulations, and clinical translation barriers of selected medicinal plants.
Gathered and synthesized secondary evidence from research articles, systematic reviews, review articles, book chapters, and electronic databases.
Evaluated bioactive phytochemical classes alongside specific plant species, primarily Azadirachta indica, Ocimum sanctum, Aloe vera, Hibiscus rosa-sinensis, and Bougainvillea spectabilis.
Identified that major phytochemical classes—including alkaloids, flavonoids, tannins, terpenoids, and phenols—exert antifungal effects via membrane permeability disruption, inhibition of ergosterol biosynthesis, oxidative stress, and metabolic interference.
Found robust evidence of antifungal efficacy against Candida species for neem, tulsi, and aloe, whereas Hibiscus rosa-sinensis and Bougainvillea spectabilis demonstrated mostly in vitro activity.
Determined that wide pharmaceutical translation remains hindered by variable bioactive concentrations, plant origin disparities, formulation issues, uncharacterized pharmacokinetics, and a lack of randomized clinical trials.

Cite This Study

Anuradha Rawat Shruti Dhiman (2026) studied this question.

synapsesocial.com/papers/6a9299338e5d7d1fc0c10f74 https://doi.org/10.5281/zenodo.22124631

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