What does this research mean for the field?

Prolonged oral ivermectin administration exhibits similar pharmacokinetic profiles in healthy and demodicosis-infested dogs and safely achieves clinical mite clearance. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To characterize the pharmacokinetics of a multi-dose ivermectin regimen in healthy versus Demodex canis-infested dogs and evaluate the relationship between drug exposure and clinical efficacy.

August 29, 2026Journal of Veterinary Pharmacology and Therapeutics

Pharmacokinetics and Efficacy Assessment of Long‐Term Ivermectin Treatment in Canine Demodicosis: Drug Disposition and Clinical Outcomes Relationship

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Authors

SMSofía MartínezUniversidad Nacional del Centro de la Provincia de Buenos Aires MSM. J. Del SoleUniversidad Nacional del Centro de la Provincia de Buenos Aires LMLaura MatéTeagasc - The Irish Agriculture and Food Development Authority

Discussion

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Implication

Pharmacokinetic study reveals prolonged oral ivermectin safely achieves complete mite clearance in dogs with demodicosis, supporting its use as an accessible therapy.

Key Points

To characterize the pharmacokinetics of a multi-dose ivermectin regimen in healthy versus Demodex canis-infested dogs and evaluate the relationship between drug exposure and clinical efficacy.
Six healthy dogs received a single oral dose of ivermectin (0.5 mg/kg) to simulate a 56-day regimen, while six dogs naturally infested with demodicosis received daily oral ivermectin (0.5 mg/kg) for 56 days.
MDR1 genotyping was conducted on infested dogs prior to therapy initiation.
Plasma ivermectin concentrations were measured via HPLC, and clinical efficacy was evaluated via skin scrapings through Day 56.
Trough plasma concentrations (Cmin) rose 3.48-fold over 56 days, aligning with Cmax increments (p > 0.05), with comparable concentration ratios between healthy (2.04) and infested dogs (2.56; p > 0.05).
Systemic exposure parameters were comparable between simulated healthy and infested dogs, including AUC0-24 (3231 vs. 3074 ng·h/mL) and accumulated AUC0-56 (315,476 vs. 294,442 ng·h/mL).
Serial skin scrapings confirmed 100% mite clearance by Day 56 in all treated infested dogs without safety issues.

Cite This Study

Martínez et al. (2026) studied this question.

synapsesocial.com/papers/6a9299338e5d7d1fc0c10fd5 https://doi.org/10.1111/jvp.70102

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Implication

Pharmacokinetic study reveals prolonged oral ivermectin safely achieves complete mite clearance in dogs with demodicosis, supporting its use as an accessible therapy.

Pharmacokinetics and Efficacy Assessment of Long‐Term Ivermectin Treatment in Canine Demodicosis: Drug Disposition and Clinical Outcomes Relationship

Discussion

Member takes

Implication

Key Points

Cite This Study

Pharmacokinetics and Efficacy Assessment of Long‐Term Ivermectin Treatment in Canine Demodicosis: Drug Disposition and Clinical Outcomes Relationship

Discussion

Member takes

Implication

Key Points

Cite This Study

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