What does this research mean for the field?

An AQbD-driven green HPLC method provides a reliable, highly sensitive, and environmentally sustainable approach for the quantitative estimation of isosorbide dinitrate in bulk and wafers. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Develop and validate a robust, environmentally sustainable high-performance liquid chromatography method for the quantitative estimation of isosorbide dinitrate in bulk drug and wafer formulations.

August 29, 2026Analytical Chemistry Letters

Green AQbD-based HPLC method for estimation of isosorbide dinitrate in bulk and wafers

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Authors

VSVanita SomasekharKLE University HSH.N. ShivakumarKLE University RPRaksha PaiIBM (United States)

Discussion

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Implication

Methodological study demonstrates an eco-friendly HPLC technique for measuring isosorbide dinitrate in bulk and wafers, suggesting an effective approach to reduce laboratory chemical waste.

Key Points

Develop and validate a robust, environmentally sustainable high-performance liquid chromatography method for the quantitative estimation of isosorbide dinitrate in bulk drug and wafer formulations.
Applied an Analytical Quality by Design framework using a C18 column (150 mm × 4.6 mm, 5 µm).
Separated analytes using a methanol/water (39:61, v/v) mobile phase at 1.01 mL/min with UV detection at 210 nm, assessing sustainability via AGREE, Eco-Scale, and BAGI tools.
Demonstrated linearity with R² = 0.9998, precision with %RSD < 2%, a limit of detection of 0.065 µg/mL, and a limit of quantification of 0.197 µg/mL.
Achieved high sustainability metrics with an AGREE score of 0.82, an Eco-Scale score of 88, and a BAGI score of 82.5.

Cite This Study

Somasekhar et al. (2026) studied this question.

synapsesocial.com/papers/6a9299338e5d7d1fc0c1100c https://doi.org/10.1080/22297928.2026.2720095

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August 29, 2026Analytical Chemistry Letters

Green AQbD-based HPLC method for estimation of isosorbide dinitrate in bulk and wafers

View Full Paper

Ask AI

Bookmark

Authors

VSVanita SomasekharKLE University HSH.N. ShivakumarKLE University RPRaksha PaiIBM (United States)

Discussion

Member takes

Implication

Methodological study demonstrates an eco-friendly HPLC technique for measuring isosorbide dinitrate in bulk and wafers, suggesting an effective approach to reduce laboratory chemical waste.

Key Points

Develop and validate a robust, environmentally sustainable high-performance liquid chromatography method for the quantitative estimation of isosorbide dinitrate in bulk drug and wafer formulations.
Applied an Analytical Quality by Design framework using a C18 column (150 mm × 4.6 mm, 5 µm).
Separated analytes using a methanol/water (39:61, v/v) mobile phase at 1.01 mL/min with UV detection at 210 nm, assessing sustainability via AGREE, Eco-Scale, and BAGI tools.
Demonstrated linearity with R² = 0.9998, precision with %RSD < 2%, a limit of detection of 0.065 µg/mL, and a limit of quantification of 0.197 µg/mL.
Achieved high sustainability metrics with an AGREE score of 0.82, an Eco-Scale score of 88, and a BAGI score of 82.5.

Cite This Study

Somasekhar et al. (2026) studied this question.

synapsesocial.com/papers/6a9299338e5d7d1fc0c1100c https://doi.org/10.1080/22297928.2026.2720095

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