What does this research mean for the field?

During acute Toxoplasma gondii infection, the host intestinal proteome undergoes profound remodeling to prioritize immune defense through cellular resource reallocation, specifically amplifying ribosome biogenesis and proteasomal degradation at the expense of tissue homeostasis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To comprehensively map and quantify temporal intestinal proteome remodeling during acute Toxoplasma gondii infection in mice.

August 29, 2026BiologyOpen Access

Integrated Proteomic Profiling Reveals Dynamic Remodeling of the Intestinal Proteome in Toxoplasma gondii-Infected C57BL/6J Mice

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To comprehensively map and quantify temporal intestinal proteome remodeling during acute Toxoplasma gondii infection in mice.
Conducted temporal, quantitative proteomic profiling of intestinal mucosa in Toxoplasma gondii-infected C57BL/6J mice.
Applied systems-level bioinformatics and protein–protein interaction network analysis to identify remodeled pathways and interactome topology.
Acute infection induced marked upregulation of acute-phase reactants and interferon-stimulated effectors alongside downregulation of proteins essential for epithelial barrier integrity and digestion.
Bioinformatic analyses revealed concurrent amplification of ribosome biogenesis and proteasomal degradation pathways, positioning the ribosome biogenesis machinery as the topological core of the host response interactome.

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Implication

Quantitative proteomic profiling reveals defense-priority resource reallocation in Toxoplasma gondii-infected mice, highlighting trade-offs between immune activation and tissue homeostasis.

Cite This Study

Zhi-lin et al. (2026) studied this question.

synapsesocial.com/papers/6a9299338e5d7d1fc0c110bb https://doi.org/10.3390/biology15171461

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Implication

Quantitative proteomic profiling reveals defense-priority resource reallocation in Toxoplasma gondii-infected mice, highlighting trade-offs between immune activation and tissue homeostasis.

Integrated Proteomic Profiling Reveals Dynamic Remodeling of the Intestinal Proteome in Toxoplasma gondii-Infected C57BL/6J Mice

Key Points

Discussion

Implication

Cite This Study

Integrated Proteomic Profiling Reveals Dynamic Remodeling of the Intestinal Proteome in Toxoplasma gondii-Infected C57BL/6J Mice

Key Points

Discussion

Implication

Cite This Study

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