Metabolomic re-analysis reveals elevated paraben metabolites in cervical and endometrial cancer patients, highlighting potential endocrine-disrupting roles in reproductive malignancies.
Paraben esters are endocrine disruptors linked to breast cancer, yet their role in other estrogen-mediated cancers remains limited. Preclinical evidence suggests that parabens accumulate in tissues and may promote carcinogenesis, while clinical data indicate widespread exposure. Our re-analysis of cervicovaginal metabolomes revealed elevated paraben metabolites in endometrial and cervical cancer patients compared with controls. Overall, longitudinal studies considering intrinsic and environmental factors are needed in assessing paraben-related cancer risk.
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Ilhan et al. (2026) studied this question.
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