What does this research mean for the field?

A STAT5B T628S mutation in γδ CD4−/CD8− double negative T-large granular lymphocytic leukemia is not universally associated with aggressive clinical behavior and can present with an indolent course. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

To report the clinical, immunophenotypic, and molecular characteristics of an indolent case of rare gamma-delta CD4-/CD8- double-negative T-large granular lymphocytic leukemia harboring a STAT5B mutation.

August 29, 2026Annals of HematologyOpen Access

Indolent γδ CD4−/CD8− double negative T-large granular lymphocytic leukemia with a STAT5B T628S mutation: a case report

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Authors

HYHee‐Jeong YoukKangwon National University CPChan Jeoung ParkUlsan College MPMi Jung ParkYong In University

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Implication

Case report reveals stable disease in rare gamma-delta T-large granular lymphocytic leukemia with a STAT5B mutation, indicating this genetic variant does not invariably drive aggressive disease.

Key Points

To report the clinical, immunophenotypic, and molecular characteristics of an indolent case of rare gamma-delta CD4-/CD8- double-negative T-large granular lymphocytic leukemia harboring a STAT5B mutation.
Evaluated a 58-year-old woman presenting with asymptomatic, persistent lymphocytosis lasting more than four years.
Conducted peripheral blood smear reviews, bone marrow biopsy, immunophenotyping, cytogenetic analysis, T-cell receptor gamma clonality assays, and targeted next-generation sequencing of whole bone marrow DNA.
Peripheral blood showed 3.65 × 10^9/L large granular lymphocytes comprising 50% of leukocytes, and bone marrow aspirate revealed 11.2% abnormal nucleated cells with a normal karyotype.
Flow cytometry identified an aberrant gamma-delta CD4-/CD8- double-negative T-cell population co-expressing CD16 and CD56, accompanied by clonal T-cell receptor gamma rearrangement.
Targeted sequencing identified a STAT5B c.1883 C>G (T628S) mutation with a 6.5% variant allele frequency, yet the patient maintained stable blood counts without therapy or clinical progression.

Cite This Study

Youk et al. (2026) studied this question.

synapsesocial.com/papers/6a92995f8e5d7d1fc0c11360 https://doi.org/10.1007/s00277-026-07256-x

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Implication

Case report reveals stable disease in rare gamma-delta T-large granular lymphocytic leukemia with a STAT5B mutation, indicating this genetic variant does not invariably drive aggressive disease.

Indolent γδ CD4−/CD8− double negative T-large granular lymphocytic leukemia with a STAT5B T628S mutation: a case report

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Implication

Key Points

Cite This Study

Indolent γδ CD4−/CD8− double negative T-large granular lymphocytic leukemia with a STAT5B T628S mutation: a case report

Discussion

Member takes

Implication

Key Points

Cite This Study

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