"Development and Characterization of Self-Nano Emulsifying Drug Delivery System to Enhance Bioavailability of Poorly Water Soluble Drug"

Q: What does this research mean for the field?

A self-nano emulsifying drug delivery system (SNEDDS) can be developed to enhance the solubilization, stability, and bioavailability of the poorly water-soluble antifungal drug itraconazole. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Mr. Adhesh R. Shinde, Dr. Sandip V Phoke, Dr. Sunil S Jaybhaye, Mr. Avinash D.Hatkar, Dr. Tharun Kumar, Mr. S. S. Dighole, Dr. N. R. Kadam

doi:10.5281/zenodo.22122443

August 27, 2026Open Access

"Development and Characterization of Self-Nano Emulsifying Drug Delivery System to Enhance Bioavailability of Poorly Water Soluble Drug"

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Key Points

To develop and characterize a self-nanoemulsifying drug delivery system aimed at enhancing the solubility and oral bioavailability of the poorly water-soluble antifungal agent itraconazole.
Designed and prepared a self-nanoemulsifying drug delivery system (SNEDDS) tailored for itraconazole.
Characterized formulation parameters to assess drug solubilization, physical stability, and delivery performance.
Nanoemulsion-based delivery platforms substantially improve the solubilization and dispersion of poorly soluble itraconazole.
The system demonstrates enhanced stability and performance metrics required to overcome limited oral bioavailability.

Implication

Formulation study demonstrates nanoemulsion-based systems improve itraconazole solubilization and stability, highlighting a promising strategy to enhance oral bioavailability.

Abstract

AbstractBackground: Itraconazole is a broad-spectrum antifungal drug characterized by pooraqueous solubility, resulting in limited oral bioavailability. Nanoemulsion-based deliverysystems offer a promising strategy to enhance drug solubilization, stability, and therapeuticperformance.

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Cite This Study

Mr. Adhesh R. Shinde, Dr. Sandip V Phoke, Dr. Sunil S Jaybhaye, Mr. Avinash D.Hatkar, Dr. Tharun Kumar, Mr. S. S. Dighole, Dr. N. R. Kadam (2026) studied this question.

synapsesocial.com/papers/6a92995f8e5d7d1fc0c11394 https://doi.org/10.5281/zenodo.22122443

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"Development and Characterization of Self-Nano Emulsifying Drug Delivery System to Enhance Bioavailability of Poorly Water Soluble Drug"

Key Points

Implication

Abstract

Discussion

Cite This Study

"Development and Characterization of Self-Nano Emulsifying Drug Delivery System to Enhance Bioavailability of Poorly Water Soluble Drug"

Key Points

Implication

Abstract

Discussion

Cite This Study

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