Computer simulations have shown that evolution of resistance to insecticides can sometimes be controlled when heavy doses of short-lived insecticides are used in the presence of a small influx of susceptible immigrants. These predictions were tested with caged populations of Musca domestica L. exposed to dieldrin. The fit between the predicted and observed course of evolution was generally good. Resistance evolved faster with a slowly decaying than with a rapidly decaying pesticide.
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Taylor et al. (1983) studied this question.