Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
August 29, 2026International Wound JournalOpen Access

The Identification of Risk Factors in the Development of Wound Healing Complications in Soft Tissue Sarcoma Patients

View Full Paper
Ask AI
Bookmark
Share

Authors

LKLuisa KriensEssen University HospitalJHJendrik HardesRuhrlandklinikWGWiebke GuderRuhrlandklinik

Discussion

Loading...

Member takes

Overview

Retrospective cohort study identifies risk factors for wound complications in soft tissue sarcoma, highlighting surgical intensity and tumor grade as key targets for therapeutic optimization.

Key Points

  • Identify clinical, surgical, and tumor-related predictors of wound-healing complications in patients undergoing soft tissue sarcoma surgery to guide therapeutic management.
  • Conducted a single-institution retrospective analysis of 318 soft tissue sarcoma patients treated between April 2019 and June 2021.
  • Evaluated demographic factors, tumor characteristics, multimodal treatments, and surgical interventions using chi-square tests, Kaplan-Meier estimates, and multivariate regression.
  • Wound-healing complications developed in 30.8% of patients and were significantly associated with increased mortality risk (p = 0.004) and longer initial hospital stay (p < 0.001).
  • Significant predictors of wound complications included high tumor grade (p = 0.018), presence of metastasis (p < 0.001), bone resection (p = 0.005), number of revisions (p < 0.001), secondary closure (p < 0.001), and relapse frequency (p = 0.012), whereas chemotherapy demonstrated a grade-stratified protective effect.

Cite This Study

Kriens et al. (2026) studied this question.

synapsesocial.com/papers/6a92997e8e5d7d1fc0c118d5https://doi.org/10.1111/iwj.71020
View Full Paper
Ask AI
Bookmark
Share