What question did this study set out to answer?

To evaluate the feasibility, acceptability, and effectiveness of tailored organizational and individual implementation strategies (EUPHORIA) in improving pre-exposure prophylaxis (PrEP) care continuum outcomes among Black cisgender women.

August 29, 2026PLoS ONEOpen Access

Enhancing uptake of PrEP for her via organizational research and individual actions (EUPHORIA): Protocol for a stepped-wedge cluster randomized trial

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Authors

AJAmy K. JohnsonLurie Children's Hospital SDSamantha A. DevlinChicago Department of Public Health CBCristina M. A. Barkowski

Discussion

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Implication

Randomized trial protocol reports implementation strategies for PrEP uptake among Black women, highlighting pathways to reduce HIV transmission disparities.

Key Points

To evaluate the feasibility, acceptability, and effectiveness of tailored organizational and individual implementation strategies (EUPHORIA) in improving pre-exposure prophylaxis (PrEP) care continuum outcomes among Black cisgender women.
Protocol for a stepped-wedge cluster randomized trial conducted across 8 family planning health centers in Cook County, Illinois.
Implements tailored organizational- and individual-level intervention strategies to improve PrEP initiation and persistence.
Utilizes a mixed-methods evaluation framework to assess implementation outcomes alongside patient-, provider-, and system-level barriers and facilitators.
Anticipated primary outcomes focus on significant increases in PrEP prescription, initiation, and persistence rates among Black women attending family planning clinics.
Post-implementation qualitative and quantitative analyses are designed to establish transferable implementation models for potential scale-up across outpatient reproductive health settings.

Cite This Study

Johnson et al. (2026) studied this question.

synapsesocial.com/papers/6a9299db8e5d7d1fc0c121ad https://doi.org/10.1371/journal.pone.0355623

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Implication

Randomized trial protocol reports implementation strategies for PrEP uptake among Black women, highlighting pathways to reduce HIV transmission disparities.

Enhancing uptake of PrEP for her via organizational research and individual actions (EUPHORIA): Protocol for a stepped-wedge cluster randomized trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Enhancing uptake of PrEP for her via organizational research and individual actions (EUPHORIA): Protocol for a stepped-wedge cluster randomized trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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