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have found that the active glycolysis of tumour tissue is destroyed by freezing and thawing.In the foregoing paper ofthis series [Boyland and Boyland, 1935] it was shown that extracts of frozen malignant tissue rapidly destroy adenylpyrophosphate-the coenzyme necessary for lactic acid formation in muscle extracts.We have found that tumour extracts convert hexosediphosphate into lactic acid, if relatively large amounts of adenylpyrophosphate are added in order to compensate for the destruction of this substiance.and Lohmann [1934, 1] have described an enzyme which causes Meyerhof
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Boyland et al. (1935) studied this question.
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