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OBJECTIVES: To summarize significant developments in Clinical Research Informatics (CRI) over the past two years and discuss future directions. METHODS: Survey of advances, open problems and opportunities in this field based on exploration of current literature. RESULTS: Recent advances are structured according to three use cases of clinical research: Protocol feasibility, patient identification/ recruitment and clinical trial execution. DISCUSSION: CRI is an evolving, dynamic field of research. Global collaboration, open metadata, content standards with semantics and computable eligibility criteria are key success factors for future developments in CRI.
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Martin Dugas (2015) studied this question.
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