INTRODUCTION Degenerative changes in the mammalian testis, due to a wide variety of causes, have been described by a number of observers. Such changes involve primarily the seminal epithelium. However, not infrequently degenerating testes also show hyperplasia of the interstitial tissue, and such hyperplasia has been interpreted as an accompaniment or a result of the degeneration of the seminal epithelium. The writer (’19) has recently described degenerative changes in the seminal epithelium and associated hyperplasia1 of the interstitial secretory tissue in the testis of the dog, following elimination of the sympathetic nerve supply to the testes and unilateral ligation and resection of the ductus def erens. The present paper embodies the results of further experimental studies undertaken in an effort to determine whether the degenerative changes which occur in the testes following operative procedures are the direct results of these operations, or whether, in some instances, they may be but an expression of the physiological state of the experimental animal.
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Albert Kuntz (1921) studied this question.