Key result
In mice with induced intracranial aneurysms, treatment with Ang 1-7 reduced mortality (from 64% to 36%; P<0.05) and the prevalence of subarachnoid hemorrhage (from 75% to 48%; P<0.05).
Why the study?
Does Angiotensin 1-7 reduce mortality and rupture of intracranial aneurysms in mice?
Population
Wild-type and Mas receptor-deficient mice with intracranial aneurysms induced by Angiotensin II-induced…
Comparison
Angiotensin 1-7 combined with elastase and… vs Elastase and Angiotensin II alone
Design
Preclinical
Authors
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Hypothesis-generating for Ang 1-7 in aneurysm stabilization; human studies required before any clinical consideration.
Does Angiotensin 1-7 reduce mortality and rupture of intracranial aneurysms in mice?
Absolute Event Rate: 36% vs 64%
p-value: p=<0.05
Angiotensin 1-7 decreases mortality and rupture of intracranial aneurysms in mice via a Mas receptor-dependent pathway, independent of blood pressure lowering.
Silva et al. (2014) studied Intracranial aneurysms. Angiotensin 1-7 vs. Elastase + Angiotensin II alone was evaluated on Mortality (p=<0.05). In mice with induced intracranial aneurysms, treatment with Ang 1-7 reduced mortality (from 64% to 36%; P<0.05) and the prevalence of subarachnoid hemorrhage (from 75% to 48%; P<0.05).
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