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January 13, 2006AJP Heart and Circulatory Physiology

Chronic angiotensin-(1–7) prevents cardiac fibrosis in DOCA-salt model of hypertension

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Why the study?

Does chronic angiotensin-(1-7) infusion prevent cardiac fibrosis in a DOCA-salt rat model of hypertension?

Population

Sprague-Dawley rats with uninephrectomy and DOCA pellet implantation, maintained on 0.9% saline solution

Comparison

Chronic angiotensin- infusion (100 ng.kg.min)… vs Sham surgery controls on normal drinking water…

Design

Preclinical

Follow-up

4 weeks

Authors

JGJustin L. GrobePreventive CardiologyAMAdam P. MeccaYale UniversityHMHaoyu MaoQinghai University

Discussion

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Implication

Should not inform clinical use in hypertension; leaves open antifibrotic effects of angiotensin-(1-7) in humans.

Structured PICO

Does chronic angiotensin-(1-7) infusion prevent cardiac fibrosis in a DOCA-salt rat model of hypertension?

P
Population
Sprague-Dawley rats with uninephrectomy and DOCA pellet implantation, maintained on 0.9% saline solution (DOCA-salt model of hypertension)
I
Intervention
Chronic angiotensin-(1-7) infusion (100 ng.kg(-1).min(-1)) via osmotic minipumps for 4 weeks
C
Comparator
Sham surgery controls on normal drinking water, and DOCA-salt animals without angiotensin-(1-7)
O
Outcome
Interstitial and perivascular collagen deposition (cardiac fibrosis)surrogate

Angiotensin-(1-7) selectively prevents cardiac fibrosis independent of blood pressure or cardiac hypertrophy in a rat model of hypertension.

Cite This Study

Grobe et al. (2006) studied this question.

synapsesocial.com/papers/6a72c2ad75498292b70bb7a8https://doi.org/10.1152/ajpheart.01170.2005

Topics

Hypertension management
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