Why the study?
Does lifetime overproduction of circulating Angiotensin-(1-7) attenuate cardiac dysfunction and remodeling in a DOCA-salt hypertension rat model?
Population
Transgenic rats overexpressing an Ang--producing fusion protein (TGR3292) and Sprague-Dawley rats subjected…
Comparison
Lifetime overproduction of circulating… vs Sprague-Dawley rats subjected to the same…
Design
Preclinical
Follow-up
30 days
Authors
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Supports Ang-(1-7) cardioprotection in hypertensive remodeling; hypothesis-generating and requires human studies before clinical consideration.
Does lifetime overproduction of circulating Angiotensin-(1-7) attenuate cardiac dysfunction and remodeling in a DOCA-salt hypertension rat model?
Increased circulating levels of Ang-(1-7) protect against cardiac dysfunction, fibrosis, and severe hypertension in a DOCA-salt rat model.
Santiago et al. (2010) studied this question.
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