Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 2, 2012AJP Heart and Circulatory Physiology

Chronic infusion of angiotensin-(1-7) into the lateral ventricle of the brain attenuates hypertension in DOCA-salt rats

View Full Paper
Ask AI
Bookmark
Share

Key result

Chronic intracerebroventricular infusion of ANG-(1-7) significantly lowered mean arterial pressure and improved baroreflex control in DOCA-salt hypertensive rats.

Why the study?

Does chronic intracerebroventricular infusion of ANG-(1-7) attenuate hypertension in DOCA-salt rats?

Population

Sprague-Dawley rats with DOCA-salt hypertension induced for seven days

Comparison

Intracerebroventricular infusion of ANG- for 14… vs 0.9% sterile saline ICV infusion for 14 days

Design

Preclinical

Follow-up

14 days

Authors

PGPriscila S. GuimarãesUniversidade Federal de AlagoasNSNivia M SantiagoDr. M.G.R. Educational and Research InstituteCXCarlos Henrique XavierUniversidade Federal de Goiás

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for central ANG-(1-7) in salt-sensitive hypertension; leaves open translation to human therapy.

Structured PICO

Does chronic intracerebroventricular infusion of ANG-(1-7) attenuate hypertension in DOCA-salt rats?

P
Population
Sprague-Dawley rats with DOCA-salt hypertension induced for seven days, followed by 14 days of treatment.
I
Intervention
Intracerebroventricular (ICV) infusion of ANG-(1-7) (200 ng/h) for 14 days
C
Comparator
0.9% sterile saline ICV infusion for 14 days
O
Outcome
Mean arterial pressure (MAP) and baroreflex control of heart rate (HR) and renal sympathetic nerve activity (RSNA) on the 21st daysurrogate

Chronic increase in ANG-(1-7) in the brain attenuates the development of DOCA-salt hypertension in rats, suggesting a central role for this peptide in cardiovascular regulation.

Cite This Study

Guimarães et al. (2012) studied DOCA-salt hypertension. Intracerebroventricular (ICV) infusion of ANG-(1-7) vs. 0.9% sterile saline was evaluated on Mean arterial pressure (MAP) and baroreflex control. Chronic intracerebroventricular infusion of ANG-(1-7) significantly lowered mean arterial pressure and improved baroreflex control in DOCA-salt hypertensive rats.

synapsesocial.com/papers/6a7dabaf8b7e38892f15055chttps://doi.org/10.1152/ajpheart.00075.2012

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Central renin-angiotensin system and the pathogenesis of DOCA-salt hypertension in rats1986 · 85 citations
  2. 2Myocardial renin is neither necessary nor sufficient to initiate or maintain ventricular hypertrophy2000 · 14 citations
  3. 3Effect of Reduced Angiotensin-Converting Enzyme Gene Expression and Angiotensin-Converting Enzyme Inhibition on Angiotensin and Bradykinin Peptide Levels in Mice2004 · 87 citations
  4. 4Sympathetic Overactivity in Hypertension*A Moving Target1996 · 237 citations
  5. 5Modulation of the baroreflex control of heart rate by angiotensin-(1–7) at the nucleus tractus solitarii of normotensive and spontaneously hypertensive rats2000 · 85 citations