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August 1, 1986AJP Heart and Circulatory Physiology

Central renin-angiotensin system and the pathogenesis of DOCA-salt hypertension in rats

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Why the study?

Does continuous ICV administration of SQ14225 reduce blood pressure in DOCA-salt hypertensive rats?

Population

DOCA (deoxycorticosterone acetate)-salt hypertensive rats

Design

Preclinical

Follow-up

7 days

Authors

YIYoshiaki ItayaKishokai Medical CorporationHSHisanori SuzukiUniversity of Arkansas at Little RockSMS MatsukawaAkebono Clinic

Discussion

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Implication

Central RAS blockade may attenuate salt-sensitive hypertension in rats; hypothesis-generating with no implications for clinical practice.

Structured PICO

Does continuous ICV administration of SQ14225 reduce blood pressure in DOCA-salt hypertensive rats?

P
Population
DOCA (deoxycorticosterone acetate)-salt hypertensive rats
I
Intervention
Continuous intracerebroventricular (ICV) administration of SQ14225 (1.25 micrograms x 0.5 microliter-1 x h-1) for 7 days
O
Outcome
Blood pressuresurrogate

Blockade of the brain renin-angiotensin system with ICV SQ14225 attenuates blood pressure increases in DOCA-salt hypertensive rats, mediated by changes in fluid intake, vasopressin, and baroreceptor reflexes.

Cite This Study

Itaya et al. (1986) studied this question.

synapsesocial.com/papers/6a70c9496c240de38cdbefb3https://doi.org/10.1152/ajpheart.1986.251.2.h261

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1No evidence for brain renin–angiotensin system activation during DOCA-salt hypertension2021 · 28 citations
  2. 2Importance of renal sympathetic tone in the development of DOCA-salt hypertension in the rat.1980 · 181 citations
  3. 3Chronic infusion of angiotensin-(1-7) into the lateral ventricle of the brain attenuates hypertension in DOCA-salt rats2012 · 67 citations
  4. 4Time course of synergistic interaction between DOCA and salt on blood pressure: roles of vasopressin and hepatic osmoreceptors2006 · 16 citations
  5. 5Blockade of Angiotensin Receptors in the Anterior Hypothalamic Preoptic Area Lowers Blood Pressure in DOCA-Salt Hypertensive Rats.2000 · 50 citations