What is the clinical evidence from this study?

Study design: Review. Population: Carotid blowout syndrome in head and neck cancer (n=140). Intervention: Carotid blowout syndrome. Primary outcome: Survival without evidence of disease.

What question did this study set out to answer?

To analyze the clinicopathologic characteristics of carotid blowout syndrome in head and neck cancer patients and evaluate treatment strategies.

July 1, 2010Annals of Otology Rhinology & Laryngology

Carotid Blowout in Patients with Head and Neck Cancer

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Key result

Carotid blowout syndrome in head and neck cancer patients is typically associated with prior radiotherapy (89%) and carries significant mortality, with only 23% surviving without evidence of disease.

Why the study?

What are the clinicopathologic features, management strategies, and outcomes of carotid blowout syndrome in patients with head and neck cancer?

Population

140 patients with head and neck cancer who developed carotid blowout syndrome, including 8 from a single…

Design

Case_series

Authors

RPRosser PowitzkyTexas A&M Health Science Center NVNilesh VasanUniversity of Oklahoma Health Sciences Center GKGreg A. KremplOklahoma City University

Discussion

Member takes

Implication

Alerts to radiotherapy-associated mortality risk; leaves optimal endovascular strategies open in head and neck cancer.

Key Points

To analyze the clinicopathologic characteristics of carotid blowout syndrome in head and neck cancer patients and evaluate treatment strategies.
Retrospective review of head and neck cancer patients diagnosed with carotid blowout syndrome at a tertiary cancer hospital between 1994 and 2009 (n=8).
Literature review of English-language publications across a 15-year window examining carotid blowout syndrome cases (21 studies, n=132).
Most patients had a history of radiotherapy (89%), cervical nodal metastasis (69%), and neck dissection (63%), with associated soft tissue necrosis in 55% and mucocutaneous fistulas in 40%.
Sentinel bleeding was present in 50% of patients, while 60% developed life-threatening hemorrhage requiring emergent intervention.
Endovascular therapy was utilized in over 90% of cases, and disease-free survival was achieved in only 23% of patients.

Structured PICO

What are the clinicopathologic features, management strategies, and outcomes of carotid blowout syndrome in patients with head and neck cancer?

Population

140 patients with head and neck cancer who developed carotid blowout syndrome, identified from a single-institution retrospective review and 21 literature studies.

Exposure

Endovascular therapy

Outcome

Clinicopathologic features, management, morbidity, and mortality of carotid blowout syndromehard clinical

Carotid blowout syndrome in head and neck cancer patients is a highly fatal complication where endovascular therapy has become the treatment of choice despite significant risks.

Cite This Study

Powitzky et al. (2010) conducted a review in Carotid blowout syndrome in head and neck cancer (n=140). Carotid blowout syndrome was evaluated on Survival without evidence of disease. Carotid blowout syndrome in head and neck cancer patients is typically associated with prior radiotherapy (89%) and carries significant mortality, with only 23% surviving without evidence of disease.

synapsesocial.com/papers/6a92a1bb0b68d46265a295c4 https://doi.org/10.1177/000348941011900709

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Carotid Blowout in Patients with Head and Neck Cancer

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Carotid Blowout in Patients with Head and Neck Cancer

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider