Replacement of unfractionated heparin by low-molecular-weight heparin for postorthopedic surgery antithrombotic prophylaxis lowers the overall risk of symptomatic thrombosis because of a lower frequency of heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is a prothrombotic immune-mediated adverse drug reaction that usually begins 5 or more days after starting heparin.[1][1] One randomized clinical trial reported a significant difference in HIT between unfractionated heparin (UFH) and low-molecular-weight