Answers are grounded in this paper and cite their sources.
The pharmacodynamics and pharmacokinetics of hirudin were studied in dogs, rabbits and rats. Hirudin proved to be a well tolerated substance with low toxicity. After intravenous injection it was eliminated with a half time of 50 to 60 min. It was nearly completely excreted through the kidneys in biologically active form. The efficacy of hirudin in preventing venous thrombosis, vascular shunt occlusion and disseminated intravascular coagulation in rats was demonstrated.
No takes yet. Share an insight, caveat, or question.
Markwárdt et al. (1982) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: