Key result
Cyanotic congenital heart disease in children was associated with increased platelet microparticles and P-selectin expression, but decreased platelet aggregation compared to acyanotic patients and controls.
Why the study?
Are platelet microparticles and platelet function profiles altered in children with congenital heart disease compared to healthy controls?
Observational (n=83)
Are platelet microparticles and platelet function profiles altered in children with congenital heart disease compared to healthy controls?
Children with cyanotic congenital heart disease exhibit overproduction of platelet microparticles and platelet activation with suppressed aggregation, which may contribute to their coagulation and hemostatic abnormalities.
Platelet microparticles (PMPs) and function profile in children with congenital heart disease (CHD) have not been widely explored. We investigated platelet aggregation, flow cytometric platelet surface receptors (P-selectin and glycoprotein (GP) IIb/IIIa) and PMPs in 23 children with cyanotic CHD (CCHD), 30 children with acyanotic CHD (ACHD) and 30 healthy controls correlating these variables to hematological and coagulation parameters including von Willebrand factor antigen (vWF Ag) as a marker of endothelial dysfunction. Hemoglobin, hematocrit (HCT), D-dimer, and vWF Ag were significantly higher in CCHD than ACHD group. Platelet MPs and P-selectin expression were increased in patients than controls, particularly in CCHD and positively correlated to HCT, D-dimer, and vWF Ag while platelet count, aggregation, and GP IIb/IIIa expression were decreased in CCHD compared with ACHD group and negatively correlated to HCT. The overproduction of PMPs and platelet activation with suppressed aggregation may be implicated in the pathogenesis of coagulation/hemostatic abnormalities in children with CCHD.
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Ismail et al. (2012) conducted an observational in Congenital heart disease (n=83). Cyanotic congenital heart disease vs. Acyanotic congenital heart disease and healthy controls was evaluated on Platelet microparticles, platelet aggregation, and platelet surface receptors. Cyanotic congenital heart disease in children was associated with increased platelet microparticles and P-selectin expression, but decreased platelet aggregation compared to acyanotic patients and controls.
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