What question did this study set out to answer?

To assess aneurysm closure rates and carrier vessel histopathological responses following endovascular treatment with porous stents, covered stent grafts, or stent-assisted coiling in an animal model.

May 30, 2005Neurosurgery

Treatment of Experimentally Induced Aneurysms with Stents

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Authors

TKTimo KringsLahey Hospital and Medical Center FHFranz J. HansUniversitätsklinikum Aachen WMWalter Möller‐HartmannUniversity of Cologne

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Implication

Comparative animal study reveals variable occlusion and vessel stenosis across stent modalities in rabbits, highlighting device-specific mechanical shortcomings.

Key Points

To assess aneurysm closure rates and carrier vessel histopathological responses following endovascular treatment with porous stents, covered stent grafts, or stent-assisted coiling in an animal model.
Induced carotid aneurysms in 30 rabbits using distal ligation combined with intraluminal elastase incubation.
Allocated 10 animals to porous stents alone, 10 to covered stent grafts, and 10 to porous stents combined with coil placement.
Evaluated outcomes at 1 month (n=5 per group) and 3 months (n=5 per group) using histopathology and immunohistochemistry to measure intimal proliferation and inflammatory infiltration.
Covered stent grafts achieved complete, stable aneurysm occlusion with minimal vessel wall proliferation; 9 of 10 parent vessels remained patent while 1 completely occluded with thrombus.
Porous stents alone achieved occlusion in 2 of 5 aneurysms at 1 month and 4 of 5 at 3 months, but triggered neointimal growth resulting in up to 40% parent vessel stenosis.
Stent-assisted coiling experienced recanalization in 1 of 5 aneurysms at 1 month and 3 of 5 at 3 months secondary to coil compaction, alongside up to 30% in-stent stenosis.

Cite This Study

Krings et al. (2005) studied this question.

synapsesocial.com/papers/6a92a31c363ee85fa149fca2 https://doi.org/10.1227/01.neu.0000159887.03290.d1

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Implication

Comparative animal study reveals variable occlusion and vessel stenosis across stent modalities in rabbits, highlighting device-specific mechanical shortcomings.

Treatment of Experimentally Induced Aneurysms with Stents

Discussion

Member takes

Implication

Key Points

Cite This Study

Treatment of Experimentally Induced Aneurysms with Stents

Discussion

Member takes

Implication

Key Points

Cite This Study

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