Key result
Antithrombin replacement during coronary artery bypass grafting in three patients with inherited antithrombin deficiency resulted in satisfactory AT levels and no thrombotic or bleeding complications.
Why the study?
Does antithrombin replacement prevent thrombotic or bleeding complications in patients with inherited antithrombin deficiency undergoing CABG?
Case Report (n=3)
Does antithrombin replacement prevent thrombotic or bleeding complications in patients with inherited antithrombin deficiency undergoing CABG?
Antithrombin replacement combined with postoperative heparin prophylaxis appears safe and effective in preventing complications during CABG in patients with inherited antithrombin deficiency.
Antithrombin replacement may be safe in this rare setting; leaves open confirmation of benefit before wider adoption.
Antithrombin (AT) replacement in coronary artery bypass grafting procedures in three individuals with inherited antithrombin deficiency is described. All three had a significant personal or family history of thrombotic disease. All patients achieved satisfactory AT levels throughout bypass and in the postoperative period. All received heparin prophylaxis in the postoperative period. None suffered thrombotic or bleeding complications.
No takes yet. Share an insight, caveat, or question.
Clark et al. (1995) conducted a case report in Inherited antithrombin deficiency undergoing coronary artery bypass grafting (n=3). Antithrombin (AT) replacement was evaluated on Thrombotic or bleeding complications. Antithrombin replacement during coronary artery bypass grafting in three patients with inherited antithrombin deficiency resulted in satisfactory AT levels and no thrombotic or bleeding complications.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: