Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1980American Journal of Clinical Pathology

Heparin Anticoagulation during Cardiopulmonary Bypass in an Antithrombin-III Deficient Patient: Implications Relative to the Etiology of Heparin Rebound

View Full Paper
Ask AI
Bookmark
Share

Key result

A patient with antithrombin-III deficiency exhibited a diminished anticoagulant response to heparin during cardiopulmonary bypass, highlighting implications for managing heparin rebound.

Population

A patient with antithrombin-III (AT-III) deficiency undergoing cardiopulmonary bypass

Design

Case_report

Authors

HSHenry B. SolowayUniversity PathologistsTCTage ChristiansenUnited States Department of Veterans Affairs

Discussion

Loading...

Member takes

Implication

Clinicians should consider AT-III deficiency in unexplained heparin resistance during CPB; single case leaves open whether monitoring or supplementation improves outcomes.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A single patient with antithrombin-III deficiency diagnosed during cardiopulmonary bypass due to a diminished response to heparin.
I
Intervention
Heparin administration
O
Outcome
Diminished anticoagulant effect

Highlights the clinical evaluation and management of AT-III deficiency manifesting as heparin resistance during cardiopulmonary bypass.

Cite This Study

Soloway et al. (1980) conducted a case report in Antithrombin-III (AT-III) deficiency (n=1). Heparin was evaluated on Anticoagulant effect. A patient with antithrombin-III deficiency exhibited a diminished anticoagulant response to heparin during cardiopulmonary bypass, highlighting implications for managing heparin rebound.

synapsesocial.com/papers/6a972fffedb8ef360a3c0426https://doi.org/10.1093/ajcp/73.5.723

Topics

Anticoagulation in AF
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Antithrombin III in Heparin Resistance1990 · 1 citations
  2. 2Anticoagulation Management in a Patient with an Acquired Antithrombin III Deficiency2001 · 15 citations
  3. 3Familial antithrombin-III deficiency during cardiopulmonary bypass: a case report2000 · 6 citations
  4. 4Normalizing Anti-Thrombin III for heparin management during routine cardiopulmonary bypass for congenital cardiothoracic surgery: A single institution practice review2024
  5. 5Exploring the Prevalence of Low Antithrombin III Level among Post-cardiac Surgery Patients and its Impact on Heparin Efficacy2024