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December 1, 2001Journal of ExtraCorporeal TechnologyOpen Access

Anticoagulation Management in a Patient with an Acquired Antithrombin III Deficiency

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Why the study?

Does fresh frozen plasma improve activated clotting time in a patient with acquired antithrombin III deficiency and heparin resistance during cardiopulmonary bypass?

Population

1 patient with a posterior myocardial infarction and previous deep venous thrombosis, requiring myocardial…

Design

Case_report

Follow-up

postoperative course

Authors

EHEileen HellerLPLeena PaulSt. Jude Children's Research Hospital

Discussion

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Implication

May support FFP in ATIII-deficient heparin resistance during CPB; hypothesis-generating case report requiring prospective trials.

Structured PICO

Does fresh frozen plasma improve activated clotting time in a patient with acquired antithrombin III deficiency and heparin resistance during cardiopulmonary bypass?

P
Population
1 patient (63-year-old, 96 Kg female) with a posterior myocardial infarction (MI) and previous deep venous thrombosis, requiring myocardial revascularization surgery and experiencing heparin resistance during cardiopulmonary bypass.
I
Intervention
Fresh frozen plasma (FFP) administered to restore adequate anticoagulation.
O
Outcome
Activated clotting time (ACT)surrogate

Fresh frozen plasma can effectively restore adequate anticoagulation in patients with acquired antithrombin III deficiency experiencing heparin resistance during cardiopulmonary bypass.

Cite This Study

Heller et al. (2001) studied this question.

synapsesocial.com/papers/6a8a769ba14d41d02f4339bdhttps://doi.org/10.1051/ject/2001334245

Topics

Anticoagulation in AF
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lack of Correlation Between Activated Clotting Time and Plasma Heparin During Cardiopulmonary Bypass1981 · 186 citations
  2. 2Actions and Interactions of Antithrombin and Heparin1975 · 470 citations