Key result
Preoperative AT-III concentrate enabled uneventful cardiopulmonary bypass in a patient with familial AT-III deficiency, but postoperative prophylactic AT-III may increase bleeding morbidity.
Population
1 60-year-old male with familial antithrombin-III deficiency undergoing coronary artery bypass surgery and…
Design
Case_report
Follow-up
immediate postoperative period
Authors
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Suggests caution with postoperative AT-III due to bleeding risk; case report leaves open optimal perioperative strategy in familial deficiency.
Case Report (n=1)
While preoperative AT-III concentrate allows for adequate anticoagulation during cardiopulmonary bypass in patients with familial AT-III deficiency, postoperative prophylactic administration should be used cautiously due to the risk of increased bleeding.
Brinks et al. (2000) conducted a case report in Familial antithrombin-III deficiency (n=1). AT-III concentrate was evaluated on Cardiopulmonary bypass success and postoperative bleeding. Preoperative AT-III concentrate enabled uneventful cardiopulmonary bypass in a patient with familial AT-III deficiency, but postoperative prophylactic AT-III may increase bleeding morbidity.
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