Summary Spleen lymphocytes that were incubated at low temperatures with fluorescent or 125I-labeled anti-Ig showed Ig molecules throughout the membrane as evidenced by immunofluorescence or electron microscopic autoradiographs. Incubation of these lymphocytes at 37°C resulted in the rapid endocytosis of the membrane anti-Ig-Ig complex.
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Unanue et al. (1972) studied this question.