Key result
A significant decrease of plasma antithrombin III levels was found in 11 of 25 members across two Italian families, with differing responses to acenocoumarin treatment in two subjects.
Observational (n=25)
The study identifies inherited antithrombin III deficiency in two Italian families and notes variable AT III level responses to oral anticoagulant treatment.
May warrant AT III screening in select families with thrombosis; leaves open optimal anticoagulant management in deficiency.
A significant decrease of plasma antithrombin III (AT III) levels, measured with four different biological and immunological methods, was found in 8 of 11 members of a Sicilian family (family DM) and in 3 of 14 members of a northern Italian family (family A). Different behaviour after oral anticoagulant treatment with acenocoumarin was seen in 2 long-term treated subjects. The propositus of family DM, who had had a long history of recurrent thrombosis, did not show any increase of AT III levels. A significant increase was, on the contrary, observed in the propositus of family A, who had suffered a recent thrombosis in a branch of the inferior mesenteric vein.
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Manotti et al. (2009) conducted an observational in Inherited Deficiency of Antithrombin III (n=25). Inherited deficiency of antithrombin III was evaluated on Plasma antithrombin III (AT III) levels. A significant decrease of plasma antithrombin III levels was found in 11 of 25 members across two Italian families, with differing responses to acenocoumarin treatment in two subjects.
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