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The effect of Dicumarol on the peritoneal transvascular transfer of T-1824-labeled plasma protein was investigated in the intact rabbit by a specially designed method. A significantly increased transfer rate was found in animals given two injections of Dicumarol 48 and 24 hours prior to testing; but determinations made 3 hours after a single injection demonstrated variable susceptibility to the drug. Prothrombin levels were depressed in every case.
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Nelson et al. (1956) studied this question.
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