Key result
Right ventricular index of myocardial performance did not differ significantly between Boxers with ARVC and controls, and was not correlated with VPC number (r = 0.21) or grade (r = -0.3).
Why the study?
Does the index of myocardial performance (IMP) detect right ventricular dysfunction in Boxers with arrhythmogenic right ventricular cardiomyopathy compared to controls?
Case-Control (n=22)
Does the index of myocardial performance (IMP) detect right ventricular dysfunction in Boxers with arrhythmogenic right ventricular cardiomyopathy compared to controls?
The index of myocardial performance did not detect significant right ventricular dysfunction in Boxers with ARVC compared to controls, suggesting either absence of dysfunction or need for more sensitive techniques.
IMP lacks sensitivity for RV dysfunction in Boxers with ARVC; leaves open need for validation of alternative indices in prospective studies.
OBJECTIVE: To use an index of myocardial performance (IMP) to assess right ventricular function in Boxers with arrhythmogenic right ventricular cardiomyopathy (ARVC). ANIMALS: 22 Boxers (12 Boxers with ARVC diagnosed by the detection of > or = 1,000 ventricular premature complexes (VPCs)/24 h and 10 Boxers with < or = 5 VPCs/24 h (control dogs). Procedures-Pulsed-wave Doppler recordings of tricuspid inflow and pulmonic outflow were acquired. Preejection period (PEP), ejection time (ET), PEP/ET, and IMP were determined for the right ventricle by use of data from separate cardiac cycles. RESULTS: A significant difference was not identified between groups for right ventricular PEP, right ventricular ET, right ventricular PEP/ET, or right ventricular IMP. Right ventricular IMP was not significantly correlated with VPC number (r = 0.21) or VPC grade (r = -0.3) in Boxers with ARVC. CONCLUSIONS AND CLINICAL RELEVANCE: Boxers with ARVC did not have significant differences in right ventricular IMP, compared with results for control Boxers. This would suggest that right ventricular dysfunction does not develop in Boxers with ARVC or that a more severe phenotype of the disease may be necessary for detection of dysfunction. Additional studies that use more sensitive techniques to evaluate myocardial function may be warranted.
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Baumwart et al. (2008) conducted a case-control in Arrhythmogenic right ventricular cardiomyopathy (n=22). Arrhythmogenic right ventricular cardiomyopathy vs. Control Boxers (≤ 5 VPCs/24 h) was evaluated on Right ventricular index of myocardial performance (IMP). Right ventricular index of myocardial performance did not differ significantly between Boxers with ARVC and controls, and was not correlated with VPC number (r = 0.21) or grade (r = -0.3).
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