Key result
Evaluation of the tafazzin (TAZ) gene and X chromosome markers revealed no linkage to dilated cardiomyopathy in Irish wolfhounds, as all dogs were monomorphic for TAZ.
Observational
The tafazzin (TAZ) gene is unlikely to be the genetic cause of dilated cardiomyopathy in Irish wolfhounds.
TAZ can be excluded in Irish wolfhounds; leaves open mapping of other loci for canine DCM.
Dilated cardiomyopathy (DCM) is a common disease in humans and dogs. Large-breed dogs and especially Irish wolfhounds belong to the frequently affected breeds. Male Irish wolfhounds show a significantly higher prevalence of DCM than females. Therefore, we evaluated X chromosome markers for linkage with DCM as well as a human candidate gene on the X chromosome. A set of X chromosomal microsatellites was genotyped in Irish wolfhound families segregating for DCM. In addition, exon and intron sequences of the tafazzin (TAZ) gene were assayed for polymorphisms segregating in these families. Statistical analysis of the microsatellite markers did not reveal linkage to DCM. Furthermore, all Irish wolfhounds included in this study were monomorphic for TAZ, and only 8 sequence differences to the Dog Genome Assembly 2.1 could be found. The results indicate that due to the lack of mutations, TAZ is unlikely to cause DCM in Irish wolfhounds.
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Philipp et al. (2007) conducted an observational in Dilated cardiomyopathy. Tafazzin (TAZ) gene and X chromosome markers was evaluated on Linkage to DCM. Evaluation of the tafazzin (TAZ) gene and X chromosome markers revealed no linkage to dilated cardiomyopathy in Irish wolfhounds, as all dogs were monomorphic for TAZ.
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